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Methylation in Cancerogenesis

It is well known that methylation of cytosine residues within CpG dinucleotides represents an important mechanism of gene expression control. Regulation of DNA methylation is crucial in many processes such as differentiation, growth and development. Hypermethylation of the gene promoter causes transcriptional silencing. Aberrant methylation may contribute to the development of a broad range of malignant tumors. Based on the foregoing, which group of genes is prone to methylation in a cancer cell?

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